WebDec 19, 2024 · Tanc2 is a large multi-domain postsynaptic scaffold protein mainly expressed in the brain. In humans, tanc2 mutations have been associated with autism spectrum disorder (ASD) and other related neurodevelopmental disorders. However, the role of tanc2 in neurodevelopment and in controlling behaviors are not fully understood. WebAssociated conditions Help. Conditions and phenotypes associated with each gene as reported by OMIM, GeneReviews and Gene. Select item 26115. TANC2. Tests. Intellectual developmental disorder with autistic features and language delay, with or without seizures. IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR ...
TANC2 - Clinical test - NIH Genetic Testing Registry (GTR) - NCBI
WebTANC2 encodes a synaptic scaffold protein interacting with multiple neuropsychiatric disorder-related postsynaptic density (PSD) proteins in dendrites. Here, we describe a new case of TANC2 gene disruption in a 17q23.3 de novo microdeletion identified by array-CGH. The patient presented craniofacial dysmorphic features, hypotonia, and severe ... WebDec 3, 2024 · Lennox-Gastaut syndrome (LGS) is a severe epileptic encephalopathy that can be caused by brain malformations or genetic mutations. Recently, genome-wide association studies have led to the identification of novel mutations associated with LGS. The TANC2 gene, encodes a synaptic scaffolding protein that interacts with other proteins at the … sundown welland
17q23.3 de novo microdeletion involving only TANC2 gene: A new …
WebApr 1, 2024 · The TANC2 gene mutations were reported in neurodevelopmental disorders and epilepsy (Guo et al., 2024), but the exact pathogenesis remains unclear. We generated an induced pluripotent stem cell line GWCMCi005-A derived from a LGS patient with pathogenic mutation in TANC2 gene, which would serve as a disease model to investigate … WebImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TANC2 antibody (ab121745) Immunohistochemical analysis of human placenta labeling TANC2 … WebSep 10, 2014 · The second fusion, TANC2–PRKCA, encodes only the first two exons of TANC2 (tetratricopeptide repeat, ankyrin repeat and CC containing 2), which contain no annotated structural domain or motif ... sundown waiver