Efferocytosis in ipf
WebJan 1, 2024 · AXL+ monocytes were generated in response to microbial products and efferocytosis in vitro. AXL kinase inhibition and down-regulation reversed attenuated … WebApr 23, 2024 · Idiopathic pulmonary fibrosis (IPF) is a relentlessly progressive disease harboring significant morbidity and mortality …
Efferocytosis in ipf
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WebMar 10, 2024 · To track both apoptosis and efferocytosis in vivo, we engineered two probes. For the apoptosis reporter, we tested multiple designs in which the cleavage by executioner caspases 3 and 7 induced fluorescence of a green fluorescent protein (GFP) (Fig. 1A; figs. S1, A to G, and S2, A to D; and supplementary materials, materials and … WebJun 21, 2024 · Idiopathic Pulmonary Fibrosis (IPF) is a chronic and progressive interstitial lung disease of unknown origin, associated with excessive ECM deposition affecting …
Webthese apoptotic cells, termed “efferocytosis,” must be efficient to prevent secondary necrosis and the release of proinflammatory cell contents that disrupt tissue homeostasis … WebEfferocytosis is accompanied by a suppression of the immune system that can explain its negative role in cancer. Additionally, defects in this process can lead to different diseases. In this review, we aim to describe the mechanism of efferocytosis and evaluate its association with the development of autoimmune diseases, airway inflammation ...
WebMar 6, 2024 · Chest X-ray. A chest X-ray shows images of your chest. This may show the scar tissue typical of pulmonary fibrosis, and it may be useful for monitoring the course of the illness and treatment. However, sometimes the chest X-ray may be normal, and further tests may be required to explain your shortness of breath. Computerized tomography … WebAug 16, 2024 · INTRODUCTION — Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease without a clear etiology. Peripheral and basal predominant pulmonary fibrosis with histopathologic and/or computed tomography (CT) findings consistent with usual interstitial pneumonia (UIP) are diagnostic of the disease.
WebJun 9, 2024 · Efficient clearance of apoptotic cells by phagocytosis, also known as efferocytosis, is fundamental to developmental biology, organ physiology, and immunology. Macrophages use multiple mechanisms ...
WebDec 1, 2012 · Efferocytosis, the specialized recognition and ingestion of apoptotic cells by phagocytes, is essential for the resolution of inflammation in the lungs and … topics good for argumentative essaysWebJun 1, 2013 · Besides preventing release of alarmins during secondary necrosis, efferocytosis profoundly impacts phagocyte function. 13 Efferocytosis was initially … topics i cannot talk in a chinese dinnerWebFeb 13, 2024 · In an efferocytosis-like manner, the PtdSer-coroneted core is in turn phagocytosed by SIMs, which synergistically terminate SIM-initiated pathological cascades and serially reestablish intra ... topics generating debate in gifted educationWebJun 1, 2024 · Efferocytosis of apoptotic cells, as discussed earlier, is a potent inducer of nuclear receptor signalling (PPAR/LXR), which leads to an anti-inflammatory and pro-efferocytosis gene expression ... topics in 2022WebEfferocytosis triggers specific downstream intracellular signal transduction pathways, for example resulting in anti-inflammatory, anti-protease and growth-promoting effects. … topics geographers studyWebThe contribution of the immune system to idiopathic pulmonary fibrosis (IPF) remains poorly understood. While most sources agree that IPF does not result from a primary immunopathogenic mechanism, evidence … topics in algebra by hersteinWebFibrosis is the result of an overly abundant deposition of extracellular matrix (ECM) due to the fact of repetitive tissue injuries and/or dysregulation of the repair process. Fibrogenesis is a pathogenetic phenomenon which is involved in different chronic human diseases, accounting for a high burden of morbidity and mortality. Despite being triggered by … topics hub