Cullins are a family of hydrophobic scaffold proteins which provide support for ubiquitin ligases (E3). All eukaryotes appear to have cullins. They combine with RING proteins to form Cullin-RING ubiquitin ligases (CRLs) that are highly diverse and play a role in myriad cellular processes, most notably protein … See more Cullin-RING ubiquitin ligases (CRLs), such as Cul1 (SCF) play an essential role in targeting proteins for ubiquitin-mediated destruction; as such, they are diverse in terms of composition and function, regulating many … See more With the exception of ANAPC2, each member of the cullin family is modified by Nedd8 and several cullins function in Ubiquitin-dependent proteolysis, a process in which the 26S See more • Cullin family - Sanger Institute website. • Cullin+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more WebZSWIM8 is the substrate receptor of a Cullin-RING E3 ubiquitin ligase; this suggests an alternative model for TDMD that does not depend on miRNA tailing and trimming. In this model, the ZSWIM8 ubiquitin ligase recognizes the conformational changes that occur upon extensive pairing to the miRNA 3′ region, which leads to polyubiquitination of AGO.
Q13617 - UniProt
WebThe cullin-RING ligases (CRLs) are a highly polymorphic E3 collection composed of a cullin backbone onto which binds carriers of activated Ub and a diverse assortment of adaptors that recruit appropriate substrates for ubiquitylation. Here, we review our current understanding of the organization and structure of CRLs in plants and their ... WebCullin-RING E3 ubiquitin ligases (CRL) control a myriad of biological processes by directing numerous protein substrates for proteasomal degradation. Key to CRL activity is the … menzel plastics perth
Regulation of cell cycle drivers by Cullin-RING ubiquitin ligases
WebThe cullin-RING ligases (CRLs) are a highly polymorphic E3 collection composed of a cullin backbone onto which binds carriers of activated Ub and a diverse assortment of … Weband ubiquitin ligation by cullin-RING E3 ligases Kheewoong Baek , Daniel C Scott 2and Brenda A Schulman1, RING E3s comprise the largest family of ubiquitin (UB) and ubiquitin-like protein (UBL) ligases. RING E3s typically promote UB or UBL transfer from the active site of an associated E2 enzyme to a distally-recruited substrate. Many RING E3s ... WebOct 2, 2024 · The last decade has revealed new roles for Cullin-RING ubiquitin ligases (CRLs) in a myriad of cellular processes, including cell cycle progression. In addition to CRL1, also named SCF (SKP1 ... menzel plastics south rd